Publications

A most updated list of publications can be found on PubMed.

Perfetto SE, Ruthirakuhan M, Ryoo SW, Wong YY, Xiong LY, Anita NZ, Caveney NA, Edgar LJ, Newman JW, Cogo-Moreira H, Swardfager W. Type 2 Diabetes Mellitus, Cognitive Performance, and Incident Dementia; Identifying Mediating Pathways and Biomarkers From the Plasma Proteome. J Neurochem. 2025. doi: 10.1111/jnc.70306. PMID: 41342355.

Bikorimana JP, Caveney NA, El-Hachem N, Mandl GA, Capobianco JA, Stanga D, Abusarah J, Hancock MA, Farah R, Gonçalves MP, Falzarano D, Liao M, Hamonic G, Liu Q, Beaudoin S, Talbot S, Rafei M. A Spike-Accum bioconjugate protein vaccine confers potent SARS-CoV-2-specific immunity. iScience. 2025. doi: 10.1016/j.isci.2025.113314. PMID: 41054531.

Li FKK, Peters SC, Worrall LJ, Sun T, Hu J, Vuckovic M, Farha M, Palacios A, Caveney NA, Brown ED, Strynadka NCJ. Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH. Nat Commun. 2025. doi: 10.1038/s41467-025-58202-w. PMID: 40185711.

Borowska MT, Liu LD, Caveney NA, Jude KM, Kim WJ, Masubuchi T, Hui E, Majzner RG, Garcia KC. Orientation-dependent CD45 inhibition with viral and engineered ligands. Sci Immunol. 2024. doi: 10.1126/sciimmunol.adp0707. PMID: 39454026.

Wang N, Waghray D, Caveney NA, Jude KM, Garcia KC. Structural insights into human MHC-II association with invariant chain. Proc Natl Acad Sci. 2024. doi: 10.1073/pnas.2403031121. PMID: 38687785.

Caveney NA, Rodriguez GE, Pollmann C, Meyer T, Borowska MT, Wilson SC, Wang N, Xiang X, Householder KD, Tao P, Su LL, Saxton RA, Piehler J, Garcia KC. Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling. Mol Cell. 2024. doi: 10.1016/j.molcel.2024.03.023. PMID: 38614096.

Bon CG, Grigg JC, Lee J, Robb CS, Caveney NA, Eltis LD, Strynadka NCJ. Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1. J Struct Biol. 2024. doi: 10.1016/j.jsb.2024.108086. PMID: 38527711.

Tsutsumi N, Masoumi Z, James SC, Tucker JA, Winkelmann H, Grey W, Picton LK, Moss L, Wilson SC, Caveney NA, Jude KM, Gati C, Piehler J, Hitchcock IS, Garcia KC. Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis. Cell. 2023. doi: 10.1016/j.cell.2023.07.037. PMID: 37633268.

Caveney NA, Tsutsumi N, Garcia KC. Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism. Elife. 2023. doi: 10.7554/eLife.86784. PMID: 37535399.

Abhiraman GC, Bruun TUJ, Caveney NA, Su LL, Saxton RA, Yin Q, Tang S, Davis MM, Jude KM, Garcia KC. A structural blueprint for interleukin-21 signal modulation. Cell Rep. 2023. doi: 10.1016/j.celrep.2023.112657. PMID: 37339051.

Saxton RA, Caveney NA, Moya-Garzon MD, Householder KD, Rodriguez GE, Burdsall KA, Long JZ, Garcia KC. Structural insights into the mechanism of leptin receptor activation. Nat Commun. 2023. doi: 10.1038/s41467-023-37169-6. PMID: 37002197.

Tsutsumi N, Hwang S, Waghray D, Hansen S, Jude KM, Wang N, Miao Y, Glassman CR, Caveney NA, Janda CY, Hannoush RN, Garcia KC. Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proc Natl Acad Sci. 2023. doi: 10.1073/pnas.2218238120. PMID: 36893265.

Caveney NA, Saxton RA, Waghray D, Glassman CR, Tsutsumi N, Hubbard SR, Garcia KC. Structural basis of Janus kinase trans-activation. Cell Rep. 2023. doi: 10.1016/j.celrep.2023.112201. PMID: 36867534.

Wilson SC, Caveney NA, Yen M, Pollmann C, Xiang X, Jude KM, Hafer M, Tsutsumi N, Piehler J, Garcia KC. Organizing structural principles of the IL-17 ligand-receptor axis. Nature. 2022. doi: 10.1038/s41586-022-05116-y. PMID: 35863378.

Caveney NA, Glassman CR, Jude KM, Tsutsumi N, Garcia KC. Structure of the IL-27 quaternary receptor signaling complex. Elife. 2022. doi: 10.7554/eLife.78463. PMID: 35579417.

Caveney NA, Workman SD, Yan R, Atkinson CE, Yu Z, Strynadka NCJ. CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution. Nat Commun. 2021. doi: 10.1038/s41467-021-23063-6. PMID: 33986273.

Lee J, Worrall LJ, Vuckovic M, Rosell FI, Gentile F, Ton AT, Caveney NA, Ban F, Cherkasov A, Paetzel M, Strynadka NCJ. Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site. Nat Commun. 2020. doi: 10.1038/s41467-020-19662-4. PMID: 33208735.

Pazos M, Peters K, Boes A, Safaei Y, Kenward C, Caveney NA, Laguri C, Breukink E, Strynadka NCJ, Simorre JP, Terrak M, Vollmer W. SPOR Proteins Are Required for Functionality of Class A Penicillin-Binding Proteins in Escherichia coli. mBio. 2020. doi: 10.1128/mBio.02796-20. PMID: 33144379.

Caveney NA, Serapio-Palacios A, Woodward SE, Bozorgmehr T, Caballero G, Vuckovic M, Deng W, Finlay BB, Strynadka NCJ. Structural and Cellular Insights into the l,d-Transpeptidase YcbB as a Therapeutic Target in Citrobacter rodentium, <i>Salmonella</i> Typhimurium, and <i>Salmonella</i> Typhi Infections. Antimicrob Agents Chemother. 2021. doi: 10.1128/AAC.01592-20. PMID: 33139287.

Caveney NA, Egan AJF, Ayala I, Laguri C, Robb CS, Breukink E, Vollmer W, Strynadka NCJ, Simorre JP. Structure of the Peptidoglycan Synthase Activator LpoP in Pseudomonas aeruginosa. Structure. 2020. doi: 10.1016/j.str.2020.03.012. PMID: 32320673.

Caveney NA, Pavlin A, Caballero G, Bahun M, Hodnik V, de Castro L, Fornelos N, Butala M, Strynadka NCJ. Structural Insights into Bacteriophage GIL01 gp7 Inhibition of Host LexA Repressor. Structure. 2019. doi: 10.1016/j.str.2019.03.019. PMID: 31056420.

Caveney NA, Caballero G, Voedts H, Niciforovic A, Worrall LJ, Vuckovic M, Fonvielle M, Hugonnet JE, Arthur M, Strynadka NCJ. Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli. Nat Commun. 2019. doi: 10.1038/s41467-019-09507-0. PMID: 31015395.

Haji-Ghassemi O, Müller-Loennies S, Brooks CL, MacKenzie CR, Caveney N, Van Petegem F, Brade L, Kosma P, Brade H, Evans SV. Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude. Biochemistry. 2019. doi: 10.1021/acs.biochem.8b00318. PMID: 30571096.

Hu J, Worrall LJ, Hong C, Vuckovic M, Atkinson CE, Caveney N, Yu Z, Strynadka NCJ. Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin. Nat Commun. 2018. doi: 10.1038/s41467-018-06298-8. PMID: 30242280.

Caveney NA, Li FK, Strynadka NC. Enzyme structures of the bacterial peptidoglycan and wall teichoic acid biogenesis pathways. Curr Opin Struct Biol. 2018. doi: 10.1016/j.sbi.2018.05.002. PMID: 29885610.